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rorc inhibitor sr2211  (Bio-Techne corporation)


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    Bio-Techne corporation rorc inhibitor sr2211
    Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or <t>SR2211</t> (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.
    Rorc Inhibitor Sr2211, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 96/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rorc inhibitor sr2211/product/Bio-Techne corporation
    Average 96 stars, based on 15 article reviews
    rorc inhibitor sr2211 - by Bioz Stars, 2026-02
    96/100 stars

    Images

    1) Product Images from "Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation"

    Article Title: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

    Journal: Nature Communications

    doi: 10.1038/s41467-022-32089-3

    Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or SR2211 (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.
    Figure Legend Snippet: Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or SR2211 (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.

    Techniques Used: Expressing, Two Tailed Test

    Single ILCP from healthy donors ( n = 16) were cultured with either 0.01% DMSO (black circles) or SR2211 (10 μ M) (red). a Frequencies of unipotent (EOMES + ILC1, EOMES-ILC1, ILC2, ILC3, None) and total multipotent clones per individual healthy donor. b Frequencies of types of multipotent clones. c Overall distributions of clones grown in either DMSO alone or SR2211. d Overall frequencies of all clones expressing IFNγ, IL-13, IL-17A and IL-22. e Cloning efficiency of donors grown in either DMSO or SR2211. Comparisons performed using ( a – b , d ) Two-way ANOVA with matching using Šidák’s multiple comparisons tests, (details in Supplementary Table ) ( c ) chi-square test (observed vs expected; details in Supplementary Table ) and e paired t-test (two-tailed) (details in Supplementary Table ). ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data represented as individual donors matched across conditions, compiled from 7 experiments. Source Data are provided as a Source Data file.
    Figure Legend Snippet: Single ILCP from healthy donors ( n = 16) were cultured with either 0.01% DMSO (black circles) or SR2211 (10 μ M) (red). a Frequencies of unipotent (EOMES + ILC1, EOMES-ILC1, ILC2, ILC3, None) and total multipotent clones per individual healthy donor. b Frequencies of types of multipotent clones. c Overall distributions of clones grown in either DMSO alone or SR2211. d Overall frequencies of all clones expressing IFNγ, IL-13, IL-17A and IL-22. e Cloning efficiency of donors grown in either DMSO or SR2211. Comparisons performed using ( a – b , d ) Two-way ANOVA with matching using Šidák’s multiple comparisons tests, (details in Supplementary Table ) ( c ) chi-square test (observed vs expected; details in Supplementary Table ) and e paired t-test (two-tailed) (details in Supplementary Table ). ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data represented as individual donors matched across conditions, compiled from 7 experiments. Source Data are provided as a Source Data file.

    Techniques Used: Cell Culture, Clone Assay, Expressing, Two Tailed Test



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    rorc inhibitor sr2211  (Bio-Techne corporation)
    96
    Bio-Techne corporation rorc inhibitor sr2211
    Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or <t>SR2211</t> (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.
    Rorc Inhibitor Sr2211, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rorc inhibitor sr2211/product/Bio-Techne corporation
    Average 96 stars, based on 1 article reviews
    rorc inhibitor sr2211 - by Bioz Stars, 2026-02
    96/100 stars
    		  Buy from Supplier

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    Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or SR2211 (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

    doi: 10.1038/s41467-022-32089-3

    Figure Lengend Snippet: Analysis of cytokine ( n = 9) and transcription factor ( n = 12) expression in differentiated human ILCP after addition of either 0.01% DMSO or SR2211 (10 uM) was assessed as described in Fig. . Representative plots in Supplementary Fig. . Expression of Group 1 ILC associated factors ( a ) IFN γ and b T-BET. Expression of Group 2 ILC associated factors ( c ) IL-13 ( d ) and GATA-3. Expression of Group 3 ILC associated factors ( e ) IL-17A and f IL-22 ( g ) RORγt. Data compared using paired T-tests (two-tailed), details in Supplementary Table . ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data are presented as individual unique donors matched across conditions. Results from 3 ( a , c , e , f ) or 4 ( b , d , g ) independent experiments. Source Data are provided as a Source Data file.

    Article Snippet: The specific RORC inhibitor SR2211 was purchased commercially (Tocris/Biotechne) and resuspended in DMSO at a stock of 100 mM.

    Techniques: Expressing, Two Tailed Test

    Single ILCP from healthy donors ( n = 16) were cultured with either 0.01% DMSO (black circles) or SR2211 (10 μ M) (red). a Frequencies of unipotent (EOMES + ILC1, EOMES-ILC1, ILC2, ILC3, None) and total multipotent clones per individual healthy donor. b Frequencies of types of multipotent clones. c Overall distributions of clones grown in either DMSO alone or SR2211. d Overall frequencies of all clones expressing IFNγ, IL-13, IL-17A and IL-22. e Cloning efficiency of donors grown in either DMSO or SR2211. Comparisons performed using ( a – b , d ) Two-way ANOVA with matching using Šidák’s multiple comparisons tests, (details in Supplementary Table ) ( c ) chi-square test (observed vs expected; details in Supplementary Table ) and e paired t-test (two-tailed) (details in Supplementary Table ). ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data represented as individual donors matched across conditions, compiled from 7 experiments. Source Data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

    doi: 10.1038/s41467-022-32089-3

    Figure Lengend Snippet: Single ILCP from healthy donors ( n = 16) were cultured with either 0.01% DMSO (black circles) or SR2211 (10 μ M) (red). a Frequencies of unipotent (EOMES + ILC1, EOMES-ILC1, ILC2, ILC3, None) and total multipotent clones per individual healthy donor. b Frequencies of types of multipotent clones. c Overall distributions of clones grown in either DMSO alone or SR2211. d Overall frequencies of all clones expressing IFNγ, IL-13, IL-17A and IL-22. e Cloning efficiency of donors grown in either DMSO or SR2211. Comparisons performed using ( a – b , d ) Two-way ANOVA with matching using Šidák’s multiple comparisons tests, (details in Supplementary Table ) ( c ) chi-square test (observed vs expected; details in Supplementary Table ) and e paired t-test (two-tailed) (details in Supplementary Table ). ns = not significant, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p < 0.001. Data represented as individual donors matched across conditions, compiled from 7 experiments. Source Data are provided as a Source Data file.

    Article Snippet: The specific RORC inhibitor SR2211 was purchased commercially (Tocris/Biotechne) and resuspended in DMSO at a stock of 100 mM.

    Techniques: Cell Culture, Clone Assay, Expressing, Two Tailed Test